Here, the authors describe an efficient Cas 9 version (Cas9) fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) and used to control gene expression with addition of Trimethoprim (TPM). They successfully used dCas9 to replace OCT4 in human cell and demonstrate that cell differentiation can be induced.
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Here, the authors describe an efficient Cas 9 version (Cas9) fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) and used to control gene expression with addition of Trimethoprim (TPM). They successfully used dCas9 to replace OCT4 in human cell and demonstrate that cell differentiation can be induced.