Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity
We found that cysteamine treatment at micromolar concentrations specifically targets MMP2, MMP9, and MMP14, leading to the inhibition of tumor invasion and migration in GBM cells overexpressing these genes. These findings suggest that clinically achievable concentrations of cysteamine are effective in inhibiting GBM invasiveness, supporting its potential use as an adjunct cancer treatment.